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Rosetta design with co-evolutionary information retains protein function

Computational protein design has the ambitious goal of crafting novel proteins that address challenges in biology and medicine. To overcome these challenges, the computational protein modeling suite Rosetta has been tailored to address various protein design tasks. Recently, statistical methods have...

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Detalles Bibliográficos
Autores principales: Schmitz, Samuel, Ertelt, Moritz, Merkl, Rainer, Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815116/
https://www.ncbi.nlm.nih.gov/pubmed/33465067
http://dx.doi.org/10.1371/journal.pcbi.1008568