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Neuroestradiol regulation of ventromedial hypothalamic nucleus 5′-AMP-activated protein kinase activity and counterregulatory hormone secretion in hypoglycemic male versus female rats

Hypoglycemia activates the ultra-sensitive energy gauge 5′-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus (VMN) gluco-regulatory neurons. The VMN is exemplified by high levels of expression of the enzyme aromatase, which converts testosterone to estradiol. This study examin...

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Detalles Bibliográficos
Autores principales: Uddin, MD Main, Briski, Karen P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815480/
https://www.ncbi.nlm.nih.gov/pubmed/33490375
http://dx.doi.org/10.3934/Neuroscience.2021006