Adipokine Leptin Co-operates With Mechanosensitive Ca(2 +)-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

In postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that tr...

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Detalles Bibliográficos
Autores principales: Acheva, Anna, Kärki, Tytti, Schaible, Niccole, Krishnan, Ramaswamy, Tojkander, Sari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815691/
https://www.ncbi.nlm.nih.gov/pubmed/33490070
http://dx.doi.org/10.3389/fcell.2020.607038