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Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy

Developmental genes are often regulated by multiple elements with overlapping activity. Yet, in most cases, the relative function of those elements and their contribution to endogenous gene expression remain poorly characterized. An example of this phenomenon is that distinct sets of enhancers have...

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Detalles Bibliográficos
Autores principales: Hörnblad, A., Bastide, S., Langenfeld, K., Langa, F., Spitz, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815712/
https://www.ncbi.nlm.nih.gov/pubmed/33469032
http://dx.doi.org/10.1038/s41467-020-20714-y