MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L)

Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates TNF-induced apoptosis through ubiquitylation of receptor-interacting protein kinase 1 (RIPK1) and cylindromatosis. Here we show that MIB2 bound and conjugated K48– and K63–linked polyubiquitin chains to a long-form of cel...

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Detalles Bibliográficos
Autores principales: Nakabayashi, Osamu, Takahashi, Hirotaka, Moriwaki, Kenta, Komazawa-Sakon, Sachiko, Ohtake, Fumiaki, Murai, Shin, Tsuchiya, Yuichi, Koyahara, Yuki, Saeki, Yasushi, Yoshida, Yukiko, Yamazaki, Soh, Tokunaga, Fuminori, Sawasaki, Tatsuya, Nakano, Hiroyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815719/
https://www.ncbi.nlm.nih.gov/pubmed/33469115
http://dx.doi.org/10.1038/s42003-020-01603-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815719/
https://www.ncbi.nlm.nih.gov/pubmed/33469115
http://dx.doi.org/10.1038/s42003-020-01603-y

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