Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster class of drugs nitrogen-containing bisphosphonates represent one of the best-known examples. Widely used to treat bone-resorptio...

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Detalles Bibliográficos
Autores principales: Park, Jaeok, Pandya, Vishal R., Ezekiel, Sean J., Berghuis, Albert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815940/
https://www.ncbi.nlm.nih.gov/pubmed/33490038
http://dx.doi.org/10.3389/fchem.2020.612728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815940/
https://www.ncbi.nlm.nih.gov/pubmed/33490038
http://dx.doi.org/10.3389/fchem.2020.612728

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