Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis

Adult hematopoietic stem cell (HSC) self-renewal requires precise control of protein synthesis, but fetal and adult HSCs have distinct self-renewal mechanisms and lineage outputs. This raises the question of whether protein synthesis rates change with age. Here, we show that protein synthesis rates...

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Detalles Bibliográficos
Autores principales: Magee, Jeffrey A., Signer, Robert A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815942/
https://www.ncbi.nlm.nih.gov/pubmed/33440178
http://dx.doi.org/10.1016/j.stemcr.2020.11.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815942/
https://www.ncbi.nlm.nih.gov/pubmed/33440178
http://dx.doi.org/10.1016/j.stemcr.2020.11.017

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