Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors

Serotonin receptor 6 (5-HT(6)R), a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area with constitutive activity, is of particular interest as a promising target for emotional impairment. Here, we found that 5-HT(6)R was highly expressed in human NSCs and activation of...

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Detalles Bibliográficos
Autores principales: Wang, Qinying, Dong, Xiaoxu, Hu, Tingting, Qu, Chao, Lu, Jing, Zhou, Yue, Li, Jinsong, Pei, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815944/
https://www.ncbi.nlm.nih.gov/pubmed/33357407
http://dx.doi.org/10.1016/j.stemcr.2020.11.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815944/
https://www.ncbi.nlm.nih.gov/pubmed/33357407
http://dx.doi.org/10.1016/j.stemcr.2020.11.015

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