NAD(+) boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways in muscle aging and diseases. Moreover, we show accumulation of amyloid-like deposits and mitochondrial dysfunction during...

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Detalles Bibliográficos
Autores principales: Romani, Mario, Sorrentino, Vincenzo, Oh, Chang-Myung, Li, Hao, de Lima, Tanes Imamura, Zhang, Hongbo, Shong, Minho, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816122/
https://www.ncbi.nlm.nih.gov/pubmed/33472069
http://dx.doi.org/10.1016/j.celrep.2020.108660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816122/
https://www.ncbi.nlm.nih.gov/pubmed/33472069
http://dx.doi.org/10.1016/j.celrep.2020.108660

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