Near Miss or Standard of Care? DPYD Screening for Cancer Patients Receiving Fluorouracil

5-fluorouracil (5-FU) and its pro-drug capecitabine are widely used anticancer agents. Most 5-FU catabolism is dependent on dihydropyrimidine dehydrogenase (DPD) encoded by the DPYD gene, and DPYD variants that reduce DPD function increase 5-FU toxicity. Most DPD deficient patients are heterozygous...

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Detalles Bibliográficos
Autores principales: Winquist, Lauren E., Sanatani, Michael, Kim, Richard B., Winquist, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816174/
https://www.ncbi.nlm.nih.gov/pubmed/33704179
http://dx.doi.org/10.3390/curroncol28010012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816174/
https://www.ncbi.nlm.nih.gov/pubmed/33704179
http://dx.doi.org/10.3390/curroncol28010012

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