Neuron‐specific deletion of presenilin enhancer2 causes progressive astrogliosis and age‐related neurodegeneration in the cortex independent of the Notch signaling

INTRODUCTION: Presenilin enhancer2 (Pen‐2) is an essential subunit of γ‐secretase, which is a key protease responsible for the cleavage of amyloid precursor protein (APP) and Notch. Mutations on Pen‐2 cause familial Alzheimer disease (AD). However, it remains unknown whether Pen‐2 regulates neuronal...

Descripción completa

Detalles Bibliográficos
Autores principales: Bi, Hui‐Ru, Zhou, Cui‐Hua, Zhang, Yi‐Zhi, Cai, Xu‐Dong, Ji, Mu‐Huo, Yang, Jian‐Jun, Chen, Gui‐Quan, Hu, Yi‐Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816208/
https://www.ncbi.nlm.nih.gov/pubmed/32961023
http://dx.doi.org/10.1111/cns.13454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816208/
https://www.ncbi.nlm.nih.gov/pubmed/32961023
http://dx.doi.org/10.1111/cns.13454

Ejemplares similares