Neuron‐specific deletion of presenilin enhancer2 causes progressive astrogliosis and age‐related neurodegeneration in the cortex independent of the Notch signaling

INTRODUCTION: Presenilin enhancer2 (Pen‐2) is an essential subunit of γ‐secretase, which is a key protease responsible for the cleavage of amyloid precursor protein (APP) and Notch. Mutations on Pen‐2 cause familial Alzheimer disease (AD). However, it remains unknown whether Pen‐2 regulates neuronal...

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Detalles Bibliográficos
Autores principales: Bi, Hui‐Ru, Zhou, Cui‐Hua, Zhang, Yi‐Zhi, Cai, Xu‐Dong, Ji, Mu‐Huo, Yang, Jian‐Jun, Chen, Gui‐Quan, Hu, Yi‐Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816208/
https://www.ncbi.nlm.nih.gov/pubmed/32961023
http://dx.doi.org/10.1111/cns.13454

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