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Engineering of targeted megabase-scale deletions in human induced pluripotent stem cells
Recurrent chromosomal deletions spanning several megabases are often found in hematological malignancies. The ability to engineer deletions in model systems to functionally study their effects on the phenotype would enable, first, determination of whether a given deletion is pathogenic or neutral an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816568/ https://www.ncbi.nlm.nih.gov/pubmed/32544417 http://dx.doi.org/10.1016/j.exphem.2020.06.001 |