Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling

Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited bioavailability. Solid dispersion systems (SD) of DCN were prepared by solvent evaporation, using hydrophilic polymers. In-vitro dissolution studies were performed and dissolution parameters were evaluated. I-Optima...

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Detalles Bibliográficos
Autores principales: Fouad, Shahinaze A., Malaak, Fady A., El-Nabarawi, Mohamed A., Abu Zeid, Khalid, Ghoneim, Amira M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816977/
https://www.ncbi.nlm.nih.gov/pubmed/33471832
http://dx.doi.org/10.1371/journal.pone.0245482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816977/
https://www.ncbi.nlm.nih.gov/pubmed/33471832
http://dx.doi.org/10.1371/journal.pone.0245482

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