Cargando…

Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling

Diacerein (DCN), a BCS II compound, suffers from poor aqueous solubility and limited bioavailability. Solid dispersion systems (SD) of DCN were prepared by solvent evaporation, using hydrophilic polymers. In-vitro dissolution studies were performed and dissolution parameters were evaluated. I-Optima...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fouad, Shahinaze A., Malaak, Fady A., El-Nabarawi, Mohamed A., Abu Zeid, Khalid, Ghoneim, Amira M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816977/ https://www.ncbi.nlm.nih.gov/pubmed/33471832 http://dx.doi.org/10.1371/journal.pone.0245482

Ejemplares similares

Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation
por: Fouad, Shahinaze A., et al.
Publicado: (2020)

Improvement of Solubility and Dissolution Properties of Clotrimazole by Solid Dispersions and Inclusion Complexes
por: Balata, Gehan, et al.
Publicado: (2011)

Improvement of In Vitro Dissolution of the Poor Water-Soluble Amlodipine Drug by Solid Dispersion with Irradiated Polyvinylpyrrolidone
por: Ghobashy, Mohamed Mohamady, et al.
Publicado: (2020)

Enhanced dissolution of poorly soluble antiviral drugs from nanoparticles of cellulose acetate based solid dispersion matrices
por: Mazumder, Sonal, et al.
Publicado: (2017)

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Zhang, Xingwang, et al.
Publicado: (2018)

Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers
por: Das, Abhisekh, et al.
Publicado: (2011)

Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution
por: Yeo, Sooho, et al.
Publicado: (2020)

Improvement in solubility of poor water-soluble drugs by solid dispersion
por: Sareen, Swati, et al.
Publicado: (2012)

How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization
por: Akram, Aasma, et al.
Publicado: (2022)

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods
por: Školáková, Tereza, et al.
Publicado: (2019)

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats
por: Cho, Hyun-Jong, et al.
Publicado: (2017)

Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and Dissolution Rate of Deferasirox
por: Farmoudeh, Ali, et al.
Publicado: (2020)

Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol(®) Enabled Amorphous Solid Dispersions
por: Gala, Urvi, et al.
Publicado: (2020)

The Self-Assembly Phenomenon of Poloxamers and Its Effect on the Dissolution of a Poorly Soluble Drug from Solid Dispersions Obtained by Solvent Methods
por: Szafraniec, Joanna, et al.
Publicado: (2019)

Development and Characterization of Eudragit(®) EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity
por: Inam, Sana, et al.
Publicado: (2022)

Thermodynamics of dissolution and infrared-spectroscopy of solid dispersions of phenacetin
por: Gerasimov, Alexander V., et al.
Publicado: (2016)

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
por: Teleki, Alexandra, et al.
Publicado: (2020)

Enhanced Transdermal Delivery of Bisoprolol Hemifumarate via Combined Effect of Iontophoresis and Chemical Enhancers: Ex Vivo Permeation/In Vivo Pharmacokinetic Studies
por: Teaima, Mahmoud H., et al.
Publicado: (2021)

Fundamental aspects of solid dispersion technology for poorly soluble drugs
por: Huang, Yanbin, et al.
Publicado: (2014)

Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
por: Tran, Thao T. D., et al.
Publicado: (2020)

Enhancement of dissolution of Telmisartan through use of solid dispersion technique - surface solid dispersion
por: Patel, Bhumika, et al.
Publicado: (2012)

Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and Dissolution Enhancer in Solid Dispersion
por: Manzoor, Mobina, et al.
Publicado: (2022)

In vitro Dissolution Testing and Pharmacokinetic Studies of Silymarin Solid Dispersion After Oral Administration to Healthy Pigs
por: Xu, Ying, et al.
Publicado: (2022)

Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method
por: Jin, Gang, et al.
Publicado: (2021)

Influence of Solid Drug Delivery System Formulation on Poorly Water-Soluble Drug Dissolution and Permeability
por: Krstić, Marko, et al.
Publicado: (2015)

Artemether-Soluplus Hot-Melt Extrudate Solid Dispersion Systems for Solubility and Dissolution Rate Enhancement with Amorphous State Characteristics
por: Fule, Ritesh A., et al.
Publicado: (2013)

In vitro Dissolution Studies on Solid Dispersions of Mefenamic Acid
por: Rao, K. R. S. Sambasiva, et al.
Publicado: (2011)

Dissolution enhancement of efavirenz by solid dispersion and PEGylation techniques
por: Madhavi, B. Bindu, et al.
Publicado: (2011)

In vitro dissolution study of atorvastatin binary solid dispersion
por: Jahan, Rahat, et al.
Publicado: (2013)

Smartcrystals for Efficient Dissolution of Poorly Water-Soluble Meloxicam
por: Ambrus, Rita, et al.
Publicado: (2022)

Surface Dissolution UV Imaging for Investigation of Dissolution of Poorly Soluble Drugs and Their Amorphous Formulation
por: Long, Chiau Ming, et al.
Publicado: (2019)

Formulation Development and Dissolution Rate Enhancement of Efavirenz by Solid Dispersion Systems
por: Koh, P. T., et al.
Publicado: (2013)

Effects of Polymers on the Drug Solubility and Dissolution Enhancement of Poorly Water-Soluble Rivaroxaban
por: Choi, Min-Jong, et al.
Publicado: (2022)

Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers
por: Dong, Luning, et al.
Publicado: (2020)

Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids from Selaginella doederleinii extract by amorphous solid dispersion
por: Chen, Bing, et al.
Publicado: (2020)

Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs
por: Tran, Thao T.D., et al.
Publicado: (2020)

Solubility Enhancement of a Poorly Water Soluble Drug by Forming Solid Dispersions using Mechanochemical Activation
por: Rojas-Oviedo, I., et al.
Publicado: (2012)

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs
por: Tekade, Avinash Ramrao, et al.
Publicado: (2020)

Multicomponent cyclodextrin system for improvement of solubility and dissolution rate of poorly water soluble drug()
por: Patel, Mayank, et al.
Publicado: (2019)

FORMULATION OF FUROSEMIDE SOLID DISPERSION WITH MICRO CRYSTALLINE CELLULOSE FOR ACHIEVE RAPID DISSOLUTION
por: Patel, Rajanikant C., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_3gk19c2u09jp68gk04lod9bphf