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1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

Immune regulatory metabolites are key features of the tumor microenvironment (TME), yet with a few exceptions, their identities remain largely unknown. Here, we profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these d...

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Detalles Bibliográficos
Autores principales: Kilgour, Marisa K., MacPherson, Sarah, Zacharias, Lauren G., Ellis, Abigail E., Sheldon, Ryan D., Liu, Elaine Y., Keyes, Sarah, Pauly, Brenna, Carleton, Gillian, Allard, Bertrand, Smazynski, Julian, Williams, Kelsey S., Watson, Peter H., Stagg, John, Nelson, Brad H., DeBerardinis, Ralph J., Jones, Russell G., Hamilton, Phineas T., Lum, Julian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817098/
https://www.ncbi.nlm.nih.gov/pubmed/33523930
http://dx.doi.org/10.1126/sciadv.abe1174