Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of...

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Detalles Bibliográficos
Autores principales: Li, Xing, Xia, Qian, Mao, Meng, Zhou, Huijuan, Zheng, Lu, Wang, Yi, Zeng, Zhen, Yan, Lulu, Zhao, Yin, Shi, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817101/
https://www.ncbi.nlm.nih.gov/pubmed/33523920
http://dx.doi.org/10.1126/sciadv.abc5539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817101/
https://www.ncbi.nlm.nih.gov/pubmed/33523920
http://dx.doi.org/10.1126/sciadv.abc5539

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