Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants

Tandem gene amplification is a frequent and dynamic source of antibiotic resistance in bacteria. Ongoing expansions and contractions of repeat arrays during population growth are expected to manifest as cell-to-cell differences in copy number (CN). As a result, a clonal bacterial culture could compr...

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Detalles Bibliográficos
Autores principales: Girgis, Hany S., DuPai, Cory D., Lund, Jessica, Reeder, Janina, Guillory, Joseph, Durinck, Steffen, Liang, Yuxin, Kaminker, Joshua, Smith, Peter A., Skippington, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817135/
https://www.ncbi.nlm.nih.gov/pubmed/33443214
http://dx.doi.org/10.1073/pnas.2021958118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817135/
https://www.ncbi.nlm.nih.gov/pubmed/33443214
http://dx.doi.org/10.1073/pnas.2021958118

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