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Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants
Tandem gene amplification is a frequent and dynamic source of antibiotic resistance in bacteria. Ongoing expansions and contractions of repeat arrays during population growth are expected to manifest as cell-to-cell differences in copy number (CN). As a result, a clonal bacterial culture could compr...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817135/ https://www.ncbi.nlm.nih.gov/pubmed/33443214 http://dx.doi.org/10.1073/pnas.2021958118 |