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Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium

Skin epithelium can accumulate a high burden of oncogenic mutations without morphological or functional consequences. To investigate the mechanism of oncogenic tolerance, we induced Hras(G12V) in single murine epidermal cells and followed them long term. We observed that Hras(G12V) promotes an early...

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Detalles Bibliográficos
Autores principales:	Sandoval, Madeline, Ying, Zhe, Beronja, Slobodan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817173/ https://www.ncbi.nlm.nih.gov/pubmed/33393458 http://dx.doi.org/10.7554/eLife.54618

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