Discovery of the EL-0052 as a potential anesthetic drug

As a γ-aminobutyric acid A receptor (GABA(A)R) inhibitor, etomidate fulfills several characteristics of an ideal anesthetic agent, such as rapid onset with rapid clearance and high potency, along with cardiovascular stability. Unfortunately, etomidate has been reported to inhibit CYP11B1 at hypnotic...

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Detalles Bibliográficos
Autores principales: Jiang, Jun-hao, Xu, Xiang-qing, Jiang, Wen-gao, Wang, Tao, Liu, Xin, Zeng, Ling-guo, Liao, Jian, Xiu, Jing-ya, Shen, Yi, Deng, Ping, Li, Qin-geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817531/
https://www.ncbi.nlm.nih.gov/pubmed/33510871
http://dx.doi.org/10.1016/j.csbj.2021.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817531/
https://www.ncbi.nlm.nih.gov/pubmed/33510871
http://dx.doi.org/10.1016/j.csbj.2021.01.002

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