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BRAF (AMP) Frequently Co-occurs With IDH1/2, TP53, and ATRX Mutations in Adult Patients With Gliomas and Is Associated With Poorer Survival Than That of Patients Harboring BRAF (V600E)
Abnormal RAS/RAF signaling plays a critical role in glioma. Although it is known that the V600E mutation of v-raf murine viral oncogene homolog B1 (BRAF (V600E)) and BRAF amplification (BRAF (AMP)) both result in constitutive activation of the RAS/RAF pathway, whether BRAF (V600E) and BRAF (AMP) hav...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817544/ https://www.ncbi.nlm.nih.gov/pubmed/33489866 http://dx.doi.org/10.3389/fonc.2020.531968 |