Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype

CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and promising effector cells for immuno-suppressive adoptive cellular therapy to fight autoimmunity and chronic inflammation. Their functional stability is critical for their clinical utility and has been correlated to the...

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Detalles Bibliográficos
Autores principales: Kressler, Christopher, Gasparoni, Gilles, Nordström, Karl, Hamo, Dania, Salhab, Abdulrahman, Dimitropoulos, Christoforos, Tierling, Sascha, Reinke, Petra, Volk, Hans-Dieter, Walter, Jörn, Hamann, Alf, Polansky, Julia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817622/
https://www.ncbi.nlm.nih.gov/pubmed/33488615
http://dx.doi.org/10.3389/fimmu.2020.609891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817622/
https://www.ncbi.nlm.nih.gov/pubmed/33488615
http://dx.doi.org/10.3389/fimmu.2020.609891

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