High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication

DNA ligase 1 (LIG1, Cdc9 in yeast) finalizes eukaryotic nuclear DNA replication by sealing Okazaki fragments using DNA end-joining reactions that strongly discriminate against incorrectly paired DNA substrates. Whether intrinsic ligation fidelity contributes to the accuracy of replication of the nuc...

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Detalles Bibliográficos
Autores principales: Williams, Jessica S., Tumbale, Percy P., Arana, Mercedes E., Rana, Julian A., Williams, R. Scott, Kunkel, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817679/
https://www.ncbi.nlm.nih.gov/pubmed/33473124
http://dx.doi.org/10.1038/s41467-020-20800-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817679/
https://www.ncbi.nlm.nih.gov/pubmed/33473124
http://dx.doi.org/10.1038/s41467-020-20800-1

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