SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells

Leukemia arises from blockage of the differentiation/maturation of hematopoietic progenitor cells at different stages with uncontrolled proliferation of leukemic cells. However, the signal pathways that block cell differentiation remain unclear. Herein we found that SUMOylation of the M2 isoform of...

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Detalles Bibliográficos
Autores principales: Xia, Li, Jiang, Yue, Zhang, Xue-Hong, Wang, Xin-Ran, Wei, Ran, Qin, Kang, Lu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817830/
https://www.ncbi.nlm.nih.gov/pubmed/33473116
http://dx.doi.org/10.1038/s41419-021-03400-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817830/
https://www.ncbi.nlm.nih.gov/pubmed/33473116
http://dx.doi.org/10.1038/s41419-021-03400-9

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