p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration

While the consequences of nuclear DNA damage have been well studied, the exact consequences of acute and selective mitochondrial DNA (mtDNA) damage are less understood. DNA damaging chemotherapeutic drugs are known to activate p53-dependent apoptosis in response to sustained nuclear DNA damage. Whil...

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Detalles Bibliográficos
Autores principales: Geden, Matthew J., Romero, Selena E., Deshmukh, Mohanish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817838/
https://www.ncbi.nlm.nih.gov/pubmed/33473103
http://dx.doi.org/10.1038/s41419-020-03373-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817838/
https://www.ncbi.nlm.nih.gov/pubmed/33473103
http://dx.doi.org/10.1038/s41419-020-03373-1

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