ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost

The impact of a compromised blood-brain barrier (BBB) on the drug treatment of intracranial tumors remains controversial. We characterize the BBB integrity in several intracranial tumor models using magnetic resonance imaging, fluorescent dyes, and autoradiography and determine the distribution and...

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Detalles Bibliográficos
Autores principales: de Gooijer, Mark C., Kemper, E. Marleen, Buil, Levi C.M., Çitirikkaya, Ceren H., Buckle, Tessa, Beijnen, Jos H., van Tellingen, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817868/
https://www.ncbi.nlm.nih.gov/pubmed/33521698
http://dx.doi.org/10.1016/j.xcrm.2020.100184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817868/
https://www.ncbi.nlm.nih.gov/pubmed/33521698
http://dx.doi.org/10.1016/j.xcrm.2020.100184

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