Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR

Agonistic monoclonal antibodies (mAbs) targeting the co-stimulatory receptor 4-1BB are among the most effective immunotherapeutic agents across pre-clinical cancer models. However, clinical development of full-length 4-1BB agonistic mAbs, has been hampered by dose-limiting liver toxicity. We have pr...

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Detalles Bibliográficos
Autores principales: Compte, Marta, Harwood, Seandean L., Martínez-Torrecuadrada, Jorge, Perez-Chacon, Gema, González-García, Patricia, Tapia-Galisteo, Antonio, Van Bergen en Henegouwen, Paul M. P., Sánchez, Aránzazu, Fabregat, Isabel, Sanz, Laura, Zapata, Juan M., Alvarez-Vallina, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817978/
https://www.ncbi.nlm.nih.gov/pubmed/33488625
http://dx.doi.org/10.3389/fimmu.2020.614363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817978/
https://www.ncbi.nlm.nih.gov/pubmed/33488625
http://dx.doi.org/10.3389/fimmu.2020.614363

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