Random epigenetic modulation of CHO cells by repeated knockdown of DNA methyltransferases increases population diversity and enables sorting of cells with higher production capacities

Chinese hamster ovary (CHO) cells produce a large share of today's biopharmaceuticals. Still, the generation of satisfactory producer cell lines is a tedious undertaking. Recently, it was found that CHO cells, when exposed to new environmental conditions, modify their epigenome, suggesting that...

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Detalles Bibliográficos
Autores principales: Weinguny, Marcus, Eisenhut, Peter, Klanert, Gerald, Virgolini, Nikolaus, Marx, Nicolas, Jonsson, Andreas, Ivansson, Daniel, Lövgren, Ann, Borth, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818401/
https://www.ncbi.nlm.nih.gov/pubmed/32662873
http://dx.doi.org/10.1002/bit.27493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818401/
https://www.ncbi.nlm.nih.gov/pubmed/32662873
http://dx.doi.org/10.1002/bit.27493

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