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CRISPR interference of nucleotide biosynthesis improves production of a single‐domain antibody in Escherichia coli
Growth decoupling can be used to optimize the production of biochemicals and proteins in cell factories. Inhibition of excess biomass formation allows for carbon to be utilized efficiently for product formation instead of growth, resulting in increased product yields and titers. Here, we used CRISPR...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818426/ https://www.ncbi.nlm.nih.gov/pubmed/32808670 http://dx.doi.org/10.1002/bit.27536 |