The Oral Bioavailability and Metabolism of Midazolam in Stable Critically Ill Children: A Pharmacokinetic Microtracing Study

Midazolam is metabolized by the developmentally regulated intestinal and hepatic drug‐metabolizing enzyme cytochrome P450 (CYP) 3A4/5. It is frequently administered orally to children, yet knowledge is lacking on the oral bioavailability in term neonates up until 1 year of age. Furthermore, the disp...

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Detalles Bibliográficos
Autores principales: van Groen, Bianca D., Krekels, Elke H. J., Mooij, Miriam G., van Duijn, Esther, Vaes, Wouter H. J., Windhorst, Albert D., van Rosmalen, Joost, Hartman, Stan J. F., Hendrikse, N. Harry, Koch, Birgit C. P., Allegaert, Karel, Tibboel, Dick, Knibbe, Catherijne A. J., de Wildt, Saskia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818442/
https://www.ncbi.nlm.nih.gov/pubmed/32403162
http://dx.doi.org/10.1002/cpt.1890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818442/
https://www.ncbi.nlm.nih.gov/pubmed/32403162
http://dx.doi.org/10.1002/cpt.1890

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