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Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2

Na(+)–K(+)–Cl(−) cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na(+), K(+), and Cl(−) ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of o...

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Autores principales: Marcoux, Andree‐Anne, Tremblay, Laurence E., Slimani, Samira, Fiola, Marie‐Jeanne, Mac‐Way, Fabrice, Garneau, Alexandre P., Isenring, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818487/
https://www.ncbi.nlm.nih.gov/pubmed/32776569
http://dx.doi.org/10.1002/jcp.29997
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author Marcoux, Andree‐Anne
Tremblay, Laurence E.
Slimani, Samira
Fiola, Marie‐Jeanne
Mac‐Way, Fabrice
Garneau, Alexandre P.
Isenring, Paul
author_facet Marcoux, Andree‐Anne
Tremblay, Laurence E.
Slimani, Samira
Fiola, Marie‐Jeanne
Mac‐Way, Fabrice
Garneau, Alexandre P.
Isenring, Paul
author_sort Marcoux, Andree‐Anne
collection PubMed
description Na(+)–K(+)–Cl(−) cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na(+), K(+), and Cl(−) ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na(+), Cl(−), Ca(2+), Mg(2) (+), and HCO(3) (−) loads. The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. The following presentation aims at discussing the physiological roles and molecular characteristics of Na(+)–K(+)–Cl(−) cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. Many of the historical and recent data that have emerged from the experiments conducted will be outlined and their larger meaning will also be placed into perspective with the aid of various hypotheses.
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spelling pubmed-78184872021-01-26 Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2 Marcoux, Andree‐Anne Tremblay, Laurence E. Slimani, Samira Fiola, Marie‐Jeanne Mac‐Way, Fabrice Garneau, Alexandre P. Isenring, Paul J Cell Physiol Review Articles Na(+)–K(+)–Cl(−) cotransporter 2 (NKCC2; SLC12A1) is an integral membrane protein that comes as three splice variants and mediates the cotranslocation of Na(+), K(+), and Cl(−) ions through the apical membrane of the thick ascending loop of Henle (TALH). In doing so, and through the involvement of other ion transport systems, it allows this nephron segment to reclaim a large fraction of the ultrafiltered Na(+), Cl(−), Ca(2+), Mg(2) (+), and HCO(3) (−) loads. The functional relevance of NKCC2 in human is illustrated by the many abnormalities that result from the inactivation of this transport system through the use of loop diuretics or in the setting of inherited disorders. The following presentation aims at discussing the physiological roles and molecular characteristics of Na(+)–K(+)–Cl(−) cotransport in the TALH and those of the individual NKCC2 splice variants more specifically. Many of the historical and recent data that have emerged from the experiments conducted will be outlined and their larger meaning will also be placed into perspective with the aid of various hypotheses. John Wiley and Sons Inc. 2020-08-10 2021-03 /pmc/articles/PMC7818487/ /pubmed/32776569 http://dx.doi.org/10.1002/jcp.29997 Text en © 2020 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Marcoux, Andree‐Anne
Tremblay, Laurence E.
Slimani, Samira
Fiola, Marie‐Jeanne
Mac‐Way, Fabrice
Garneau, Alexandre P.
Isenring, Paul
Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title_full Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title_fullStr Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title_full_unstemmed Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title_short Molecular characteristics and physiological roles of Na(+)–K(+)–Cl(−) cotransporter 2
title_sort molecular characteristics and physiological roles of na(+)–k(+)–cl(−) cotransporter 2
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818487/
https://www.ncbi.nlm.nih.gov/pubmed/32776569
http://dx.doi.org/10.1002/jcp.29997
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