An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes

Relacorilant is a selective modulator of the glucocorticoid receptor in development for the treatment of several serious diseases. The widely used cocktail method was employed to assess relacorilant's effect on various cytochrome P450 (CYP) drug metabolizing enzymes in vitro and in vivo. Inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Custodio, Joseph M., Donaldson, Kirsteen M., Hunt, Hazel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Drug Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818505/
https://www.ncbi.nlm.nih.gov/pubmed/32869328
http://dx.doi.org/10.1002/jcph.1731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818505/
https://www.ncbi.nlm.nih.gov/pubmed/32869328
http://dx.doi.org/10.1002/jcph.1731

Ejemplares similares