Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers

Venglustat is a small‐molecule glucosylceramide synthase (GCS) inhibitor designed to reduce the production of glucosylceramide (GL‐1) and thus is expected to substantially reduce formation of glucosylceramide‐based glycosphingolipids. Because of its effect on glycosphingolipid formation, GCS inhibit...

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Detalles Bibliográficos
Autores principales: Peterschmitt, M. Judith, Crawford, Nigel P. S., Gaemers, Sebastiaan J. M., Ji, Allena J., Sharma, Jyoti, Pham, Theresa T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818513/
https://www.ncbi.nlm.nih.gov/pubmed/32851809
http://dx.doi.org/10.1002/cpdd.865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818513/
https://www.ncbi.nlm.nih.gov/pubmed/32851809
http://dx.doi.org/10.1002/cpdd.865

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