Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells

BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine by PEGylated arginine deiminase (ADI-PEG20),...

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Detalles Bibliográficos
Autores principales: Rogers, Leonard C., Zhou, Jing, Baker, Adriana, Schutt, Charles R., Panda, Prashanta K., Van Tine, Brian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818940/
https://www.ncbi.nlm.nih.gov/pubmed/33478587
http://dx.doi.org/10.1186/s40170-021-00238-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818940/
https://www.ncbi.nlm.nih.gov/pubmed/33478587
http://dx.doi.org/10.1186/s40170-021-00238-9

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