Cargando…

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells

BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle. Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine by PEGylated arginine deiminase (ADI-PEG20),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rogers, Leonard C., Zhou, Jing, Baker, Adriana, Schutt, Charles R., Panda, Prashanta K., Van Tine, Brian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818940/ https://www.ncbi.nlm.nih.gov/pubmed/33478587 http://dx.doi.org/10.1186/s40170-021-00238-9

Ejemplares similares

Amino Acid Uptake Measured by [(18)F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas
por: Prudner, Bethany Cheree, et al.
Publicado: (2018)

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression
por: Tsai, Wen-Bin, et al.
Publicado: (2017)

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
por: Kremer, Jeff Charles, et al.
Publicado: (2017)

Gas6/Axl in arginine-starvation therapy
por: Tsai, Wen-Bin, et al.
Publicado: (2015)

Death of Mycobacterium tuberculosis by l-arginine starvation
por: Mizrahi, Valerie, et al.
Publicado: (2018)

A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
por: Bean, Gregory R, et al.
Publicado: (2016)

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation
por: Long, Yan, et al.
Publicado: (2016)

Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
por: Brashears, Caitlyn B., et al.
Publicado: (2020)

Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers
por: Rogers, Leonard C., et al.
Publicado: (2019)

Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
por: Zhang, Yiming, et al.
Publicado: (2022)

Chromatin accessibility governs the differential response of cancer and T cells to arginine starvation
por: Crump, Nicholas T., et al.
Publicado: (2021)

Arginine deprivation in KB cells. II. Characterization of the DNA synthesized during starvation
Publicado: (1977)

Chromatophagy: Autophagy goes nuclear and captures broken chromatin during arginine-starvation
por: Kung, Hsing-Jien, et al.
Publicado: (2015)

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
por: Cheng, Chun-Ting, et al.
Publicado: (2018)

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges
por: Phillips, Melissa M., et al.
Publicado: (2013)

Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development
por: Goldman-Pinkovich, Adele, et al.
Publicado: (2020)

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy
por: Kuo, Macus Tien, et al.
Publicado: (2021)

The Free Energy Barrier for Arginine Gating Charge Translation Is Altered by Mutations in the Voltage Sensor Domain
por: Schwaiger, Christine S., et al.
Publicado: (2012)

An engineered l-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice
por: Hartenbach, Shizuka, et al.
Publicado: (2007)

Arginine-dependent immune responses
por: Martí i Líndez, Adrià-Arnau, et al.
Publicado: (2021)

Editorial: Pharmacology of L-Arginine and L-Arginine-Rich Food
por: Poeggeler, Burkhard, et al.
Publicado: (2021)

Arginine metabolism and the role of arginine deiminase-producing microorganisms in kimchi fermentation
por: Jung, Sera, et al.
Publicado: (2022)

P01: ARGININE STARVATION IN MULTIPLE MYELOMA MICROENVIRONMENT CONVEYS BORTEZOMIB REFRACTORINESS VIA TLR4 PATHWAY.
por: Romano, A, et al.
Publicado: (2022)

Acute hemodynamic effects of L-arginine, arginine nitrate, and arginine peptide on exercise-induced vasodilation and blood flow in healthy men
por: Falcone, Paul H, et al.
Publicado: (2015)

The Ergogenic Potential of Arginine
por: Campbell, Bill I, et al.
Publicado: (2004)

ADP-ribosylation of arginine
por: Laing, Sabrina, et al.
Publicado: (2010)

Arginine and Endothelial Function
por: Gambardella, Jessica, et al.
Publicado: (2020)

AhrC Negatively Regulates Streptococcus mutans Arginine Biosynthesis
por: Jing, Meiling, et al.
Publicado: (2022)

Arginine methylation augments Sbp1 function in translation repression and decapping
por: Bhatter, Nupur, et al.
Publicado: (2019)

Post-Translationally Regulated Protein Arginine-to-Proline Conversion in Alzheimer’s Brains
por: Suzuki, Yuichiro Justin
Publicado: (2022)

Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor Exploits Competition between L-Arginine Ligands and Resident Arginine Residues
por: Strawn, Rebecca, et al.
Publicado: (2010)

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
por: Feun, L G, et al.
Publicado: (2012)

The Learned Ass
Publicado: (1896)

Contribution of the Twin-Arginine Translocation System to the Intracellular Survival of Salmonella Typhimurium in Dictyostelium discoideum
por: Urrutia, Ítalo M., et al.
Publicado: (2018)

The role of arginine and arginine-metabolizing enzymes during Giardia – host cell interactions in vitro
por: Stadelmann, Britta, et al.
Publicado: (2013)

Arginine-Selective Chemical Labeling Approach for Identification and Enrichment of Reactive Arginine Residues in Proteins
por: Wanigasekara, Maheshika S. K., et al.
Publicado: (2018)

Arginine Side‐Chain Hydrogen Exchange: Quantifying Arginine Side‐Chain Interactions in Solution
por: Mackenzie, Harold W., et al.
Publicado: (2018)

Arginine and Arginine-Rich Peptides as Modulators of Protein Aggregation and Cytotoxicity Associated With Alzheimer’s Disease
por: Mamsa, Somayra S. A., et al.
Publicado: (2021)

The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
por: Bai, Xuemei, et al.
Publicado: (2022)

Arginine Is a Novel Drug Target for Arginine Decarboxylase in Human Colorectal Cancer Cells
por: Wei, Xinlei, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2p7g4vmjj54vboppihti4bj3q2