Non-SUMOylated CRMP2 decreases Na(V)1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel Na(V)1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2). When not SUMOylated, CRMP2 forms a complex with the endocyti...

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Detalles Bibliográficos
Autores principales: Gomez, Kimberly, Ran, Dongzhi, Madura, Cynthia L., Moutal, Aubin, Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819318/
https://www.ncbi.nlm.nih.gov/pubmed/33478555
http://dx.doi.org/10.1186/s13041-020-00714-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819318/
https://www.ncbi.nlm.nih.gov/pubmed/33478555
http://dx.doi.org/10.1186/s13041-020-00714-1

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