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Non-SUMOylated CRMP2 decreases Na(V)1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Voltage-gated sodium channels are key players in neuronal excitability and pain signaling. Functional expression of the voltage-gated sodium channel Na(V)1.7 is under the control of SUMOylated collapsin response mediator protein 2 (CRMP2). When not SUMOylated, CRMP2 forms a complex with the endocyti...

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Detalles Bibliográficos
Autores principales:	Gomez, Kimberly, Ran, Dongzhi, Madura, Cynthia L., Moutal, Aubin, Khanna, Rajesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819318/ https://www.ncbi.nlm.nih.gov/pubmed/33478555 http://dx.doi.org/10.1186/s13041-020-00714-1

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