Cost-effectiveness of a Pharmacogenomic Test for Stratified Isoniazid Dosing in Treatment of Active Tuberculosis

BACKGROUND: There is marked interindividual variability in metabolism and resulting toxicity and effectiveness of drugs used for tuberculosis treatment. For isoniazid, mutations in the N-acetyltransferase 2 (NAT2) gene explain >88% of pharmacokinetic variability. However, weight-based dosing rema...

Descripción completa

Detalles Bibliográficos
Autores principales: Rens, Neil E, Uyl-de Groot, Carin A, Goldhaber-Fiebert, Jeremy D, Croda, Julio, Andrews, Jason R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Major Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819527/
https://www.ncbi.nlm.nih.gov/pubmed/31905381
http://dx.doi.org/10.1093/cid/ciz1212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819527/
https://www.ncbi.nlm.nih.gov/pubmed/31905381
http://dx.doi.org/10.1093/cid/ciz1212

Ejemplares similares