Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear. We generated mesenchymal progenitor-specific (Runx1(f/f)Twist2-Cre) and osteoblast-specific (Runx1(f/f)Col1α1-Cre) conditional knockout (Runx1 CKO) mice. The mutant CKO mice with normal skeletal development d...

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Detalles Bibliográficos
Autores principales: Tang, Chen-Yi, Wu, Mengrui, Zhao, Dongfeng, Edwards, Diep, McVicar, Abigail, Luo, Yuan, Zhu, Guochun, Wang, Yongjun, Zhou, Hou-De, Chen, Wei, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819607/
https://www.ncbi.nlm.nih.gov/pubmed/33476325
http://dx.doi.org/10.1371/journal.pgen.1009233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819607/
https://www.ncbi.nlm.nih.gov/pubmed/33476325
http://dx.doi.org/10.1371/journal.pgen.1009233

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