Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression

Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1, a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of-function approach and a systems biology strategy we now show that EED, an essential PcG component, acts in the arcuat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, Hollis, Aylwin, Carlos F., Toro, Carlos A., Ojeda, Sergio R., Lomniczi, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819995/
https://www.ncbi.nlm.nih.gov/pubmed/33479437
http://dx.doi.org/10.1038/s41598-021-81689-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819995/
https://www.ncbi.nlm.nih.gov/pubmed/33479437
http://dx.doi.org/10.1038/s41598-021-81689-4

Ejemplares similares