Cargando…

Ex vivo culture of intact human patient derived pancreatic tumour tissue

The poor prognosis of pancreatic ductal adenocarcinoma (PDAC) is attributed to the highly fibrotic stroma and complex multi-cellular microenvironment that is difficult to fully recapitulate in pre-clinical models. To fast-track translation of therapies and to inform personalised medicine, we aimed t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kokkinos, John, Sharbeen, George, Haghighi, Koroush S., Ignacio, Rosa Mistica C., Kopecky, Chantal, Gonzales-Aloy, Estrella, Youkhana, Janet, Timpson, Paul, Pereira, Brooke A., Ritchie, Shona, Pandzic, Elvis, Boyer, Cyrille, Davis, Thomas P., Butler, Lisa M., Goldstein, David, McCarroll, Joshua A., Phillips, Phoebe A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820421/ https://www.ncbi.nlm.nih.gov/pubmed/33479301 http://dx.doi.org/10.1038/s41598-021-81299-0

Ejemplares similares

Does the Microenvironment Hold the Hidden Key for Functional Precision Medicine in Pancreatic Cancer?
por: Kokkinos, John, et al.
Publicado: (2021)

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity
por: Sharbeen, George, et al.
Publicado: (2016)

Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer
por: Sharbeen, George, et al.
Publicado: (2015)

Delineating the Role of βIV-Tubulins in Pancreatic Cancer: βIVb-Tubulin Inhibition Sensitizes Pancreatic Cancer Cells to Vinca Alkaloids()()
por: Sharbeen, G., et al.
Publicado: (2016)

Potential applications of nanotechnology for the diagnosis and treatment of pancreatic cancer
por: McCarroll, Joshua, et al.
Publicado: (2014)

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer
por: McCarroll, Joshua A., et al.
Publicado: (2014)

βIII-Tubulin: A novel mediator of chemoresistance and metastases in pancreatic cancer
por: McCarroll, Joshua A., et al.
Publicado: (2014)

The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis
por: Ritchie, Shona, et al.
Publicado: (2021)

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer
por: Chambers, Cecilia R., et al.
Publicado: (2021)

β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells
por: Parker, Amelia L, et al.
Publicado: (2018)

Imaging Modalities for Early Detection of Pancreatic Cancer: Current State and Future Research Opportunities
por: Farr, Katherina P., et al.
Publicado: (2022)

ROR1 and ROR2 expression in pancreatic cancer
por: Liu, Dongli, et al.
Publicado: (2021)

βIII‐tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c‐Met positive non‐small cell lung cancer cells
por: Brayford, Simon, et al.
Publicado: (2022)

Defined Microenvironments Trigger In Vitro Gastrulation in Human Pluripotent Stem Cells
por: Srivastava, Pallavi, et al.
Publicado: (2022)

Quantifying cilia beat frequency using high‐speed video microscopy: Assessing frame rate requirements when imaging different ciliated tissues
por: Scopulovic, Luke, et al.
Publicado: (2022)

How to exploit different endocytosis pathways to allow selective delivery of anticancer drugs to cancer cells over healthy cells
por: Cong, Vu Thanh, et al.
Publicado: (2021)

The effect of locally delivered cisplatin is dependent on an intact immune function in an experimental glioma model
por: Enríquez Pérez, Julio, et al.
Publicado: (2019)

Disruption of membrane cholesterol organization impairs the activity of PIEZO1 channel clusters
por: Ridone, Pietro, et al.
Publicado: (2020)

Quantifying Intracellular Viral Pathogen: Specimen Preparation, Visualization and Quantification of Multiple Immunofluorescent Signals in Fixed Human Airway Epithelium Cultured at Air-Liquid Interface
por: Wong, Sharon L., et al.
Publicado: (2022)

Application of Rapid Fluorescence Lifetime Imaging Microscopy (RapidFLIM) to Examine Dynamics of Nanoparticle Uptake in Live Cells
por: Ahmed-Cox, Aria, et al.
Publicado: (2022)

Scalable Electrophysiology in Intact Small Animals with Nanoscale Suspended Electrode Arrays
por: Gonzales, Daniel L., et al.
Publicado: (2017)

A study of the $\tau$ Lepton polarization in $Z^0$ decays
por: Altoon, Butrus Youkhana
Publicado: (2020)

Intact stability /
por: Moore, Colin S.
Publicado: (2010)

Molecular and Functional Characteristics of Airway Epithelium under Chronic Hypoxia
por: Wong, Sharon L., et al.
Publicado: (2023)

Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury
por: Park, Mijeong, et al.
Publicado: (2019)

Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation
por: Park, Mijeong, et al.
Publicado: (2022)

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness
por: Hinde, Elizabeth, et al.
Publicado: (2016)

A Challenging Diagnosis of Two Ruptured and Intact Pulmonary Echinococcal Cysts in a 54-Year-Old Woman: A Case Report
por: Haghighi, Leila, et al.
Publicado: (2021)

Carbon pools of an intact forest in Gabon
por: Gautam, Sishir, et al.
Publicado: (2012)

Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains
por: Abu-Arish, Asmahan, et al.
Publicado: (2019)

MRI of intact plants
por: Van As, Henk, et al.
Publicado: (2009)

Keeping colliders intact
Publicado: (2009)

The Tolerance of Intact Mucosa
Publicado: (1929)

Intact Excision of a Mesenteric Pseudocyst
por: Kaushik, Kumar, et al.
Publicado: (2023)

On the use of virtual simulation in radiotherapy of the intact breast
por: Tomé, Wolfgang A., et al.
Publicado: (2000)

Investigating the relationship between the demographic variables associated with suicide in different seasons, among suicidal people in the Shahid Mohammadi Hospital, Bandar Abass, Iran
por: Haghighi, Hamid, et al.
Publicado: (2015)

“Sightblind”: Perceptual Deficits in the “Intact” Visual Field
por: Bola, Michał, et al.
Publicado: (2013)

Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells
por: Trifonova, Radiana T., et al.
Publicado: (2018)

Lipid-driven CFTR clustering is impaired in cystic fibrosis and restored by corrector drugs
por: Abu-Arish, Asmahan, et al.
Publicado: (2022)

Broken Tumor, Intact Courage
por: Kaushik, Dharam
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1ck5eq29atb5h7t8gt94o5iubj