Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) that differ...

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Detalles Bibliográficos
Autores principales: Reijneveld, Josephine F., Holzheimer, Mira, Young, David C., Lopez, Kattya, Suliman, Sara, Jimenez, Judith, Calderon, Roger, Lecca, Leonid, Murray, Megan B., Ishikawa, Eri, Yamasaki, Sho, Minnaard, Adriaan J., Moody, D. Branch, Van Rhijn, Ildiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820438/
https://www.ncbi.nlm.nih.gov/pubmed/33479373
http://dx.doi.org/10.1038/s41598-021-81474-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820438/
https://www.ncbi.nlm.nih.gov/pubmed/33479373
http://dx.doi.org/10.1038/s41598-021-81474-3

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