Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway

Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1 and ATase2, which acetylate nascent polypeptide...

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Detalles Bibliográficos
Autores principales: Dieterich, Inca A., Cui, Yusi, Braun, Megan M., Lawton, Alexis J., Robinson, Nicklaus H., Peotter, Jennifer L., Yu, Qing, Casler, Jason C., Glick, Benjamin S., Audhya, Anjon, Denu, John M., Li, Lingjun, Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820588/
https://www.ncbi.nlm.nih.gov/pubmed/33479349
http://dx.doi.org/10.1038/s41598-021-81447-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820588/
https://www.ncbi.nlm.nih.gov/pubmed/33479349
http://dx.doi.org/10.1038/s41598-021-81447-6

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