Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria. Recently, EMR2 was found to activate NLRP3 inflammasome i...

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Detalles Bibliográficos
Autores principales: I, Kuan-Yu, Tseng, Wen-Yi, Wang, Wen-Chih, Gordon, Siamon, Ng, Kwai-Fong, Lin, Hsi-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820815/
https://www.ncbi.nlm.nih.gov/pubmed/33488598
http://dx.doi.org/10.3389/fimmu.2020.602016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820815/
https://www.ncbi.nlm.nih.gov/pubmed/33488598
http://dx.doi.org/10.3389/fimmu.2020.602016

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