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Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria. Recently, EMR2 was found to activate NLRP3 inflammasome i...

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Detalles Bibliográficos
Autores principales:	I, Kuan-Yu, Tseng, Wen-Yi, Wang, Wen-Chih, Gordon, Siamon, Ng, Kwai-Fong, Lin, Hsi-Hsien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820815/ https://www.ncbi.nlm.nih.gov/pubmed/33488598 http://dx.doi.org/10.3389/fimmu.2020.602016

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