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Using Mutability Landscapes To Guide Enzyme Thermostabilization
Thermostabilizing enzymes while retaining their activity and enantioselectivity for applied biocatalysis is an important topic in protein engineering. Rational and computational design strategies as well as directed evolution have been used successfully to thermostabilize enzymes. Herein, we describ...
Autores principales: | Guo, Chao, Ni, Yan, Biewenga, Lieuwe, Pijning, Tjaard, Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821111/ https://www.ncbi.nlm.nih.gov/pubmed/32790123 http://dx.doi.org/10.1002/cbic.202000442 |
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