Structure‐based non‐nucleoside inhibitor design: Developing inhibitors that are effective against resistant mutants

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) inhibit reverse transcription and block the replication of HIV‐1. Currently, NNRTIs are usually used as part of a three‐drug combination given to patients as antiretroviral therapy. These combinations involve other classes of anti‐HIV‐1 drugs,...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Steven J., Pauly, Gary T., Hewlett, Katharine, Schneider, Joel P., Hughes, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821153/
https://www.ncbi.nlm.nih.gov/pubmed/32743937
http://dx.doi.org/10.1111/cbdd.13766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821153/
https://www.ncbi.nlm.nih.gov/pubmed/32743937
http://dx.doi.org/10.1111/cbdd.13766

Ejemplares similares