Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐x(L) and MCL‐1 through Noncanonical Structural Motifs

Abstract: The BCL‐2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL‐2 family regulators of apoptosis are useful as probes to understand cell biology and apoptotic signalling pathways, and as st...

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Detalles Bibliográficos
Autores principales: Miles, Jennifer A., Hobor, Fruzsina, Trinh, Chi H., Taylor, James, Tiede, Christian, Rowell, Philip R., Jackson, Brian R., Nadat, Fatima A., Ramsahye, Pallavi, Kyle, Hannah F., Wicky, Basile I. M., Clarke, Jane, Tomlinson, Darren C., Wilson, Andrew J., Edwards, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821230/
https://www.ncbi.nlm.nih.gov/pubmed/32961017
http://dx.doi.org/10.1002/cbic.202000585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821230/
https://www.ncbi.nlm.nih.gov/pubmed/32961017
http://dx.doi.org/10.1002/cbic.202000585

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