Population Pharmacokinetic Analysis of BMS‐986166, a Novel Selective Sphingosine‐1‐Phosphate‐1 Receptor Modulator, and Exposure‐Response Assessment of Lymphocyte Counts and Heart Rate in Healthy Participants

Sphingosine‐1‐phosphate (S1P) binding to the S1P‐1 receptor (S1P1R) controls the egress of lymphocytes from lymphoid organs and targets modulation of immune responses in autoimmune diseases. Pharmacologic modulation of S1P receptors has been linked to heart rate reduction. BMS‐986166, a prodrug of t...

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Detalles Bibliográficos
Autores principales: Bihorel, Sébastien, Singhal, Shalabh, Shevell, Diane, Sun, Huadong, Xie, Jenny, Basdeo, Shenita, Liu, Ang, Dutta, Santanu, Ludwig, Elizabeth, Huang, Hannah, Lin, Kuan‐ju, Fura, Aberra, Throup, John, Girgis, Ihab G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821288/
https://www.ncbi.nlm.nih.gov/pubmed/33090733
http://dx.doi.org/10.1002/cpdd.878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821288/
https://www.ncbi.nlm.nih.gov/pubmed/33090733
http://dx.doi.org/10.1002/cpdd.878

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